More than 48,000 Americans will be diagnosed with oral cancer this year, and it will kill almost 10,000 of those people. Sadly, only 57% of the more than 48,000 diagnosed this year will still be living five years from now. These numbers are frightening, and while some of the risk factors, such as the consumption of alcohol and tobacco, are well-known nearly 25% of new oral cancer diagnoses have no known risk factors. In fact, the U.S. has seen a five-fold increase in oral cancer patients under age 40 that have no immediately recognizable risk factors.